Integrating genomics with hierarchical physical models of DNA and chromosomes

Centre Blaise Pascal, ENS Lyon, France
June 22-26, 2015

GenPhysChrom Website

Organisers

• Ralf Everaers, ENS de Lyon
• Sarah Harris, University of Leeds, UK
• Cedric Vaillant, ENS de Lyon

Administrative coordination: Samantha Barendson, CBP - ENS de Lyon

We propose to focus a multidisciplinary CECAM workshop on the analysis and the modeling of the 3D organisation of the genome. In particular, we want explore, if it is possible to predict genome folding as a function of the DNA sequence and epigenetic state by adapting models and tools developed in computational soft matter physics to study structure formation in polymer systems, and whether this will enable us to understand how these genomes are regulated. The workshop will debate whether for systems of this enormous complexity, the “bottom up” ab initio approaches that have proven so successful in the physical sciences can every prove as useful in biology.